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CT-based Analysis of Vascular Tree Abnormalities in Different Phenotypes of COVID-19 Pneumonia

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@article{IJASEIT12579,
   author = {Gihad Ibrahim and Ahmed Hassan},
   title = {CT-based Analysis of Vascular Tree Abnormalities in Different Phenotypes of COVID-19 Pneumonia},
   journal = {International Journal on Advanced Science, Engineering and Information Technology},
   volume = {12},
   number = {3},
   year = {2022},
   pages = {1215--1221},
   keywords = {COVID-19 pneumonia; SARS-CoV-2; COVID-19 phenotypes; vascular tree analysis.},
   abstract = {In this paper, Computed Tomography (CT) images of six confirmed COVID-19 patients were analyzed in order to investigate the physiological abnormalities in the vascular tree in response to the disease-induced hypoxia. The CT images were classified into an L-type and H-type groups based on the cumulative voxel distribution of the CT scan. A 3-Dimentional model of the vascular tree was reconstructed out of each CT image following a computational framework. Then, the Cross-Sectional Area (CSA) of the vessels belonging to each vascular tree was computed. The acquired results were compared against averaged measurements of three healthy subjects that were computed following the same approach. The results showed that as the severity of COVID-19 lean towards H-type phenotype, signs of vasoconstriction in small blood vessels with a CSA less than 10 mm2 tend to decreases, whereas signs of vasodilation in medium to large blood vessels increases. The intensity of dilated blood vessels proximal to consolidated areas of the lung was found to increase significantly as the disease progresses in the lungs. Furthermore, signs of vasoconstriction and vasodilation in the vascular tree were observed in all lobes of the lung in both phenotypes including seemingly healthy lobes. The results in this paper are suggestive of intrapulmonary blood flow shunting towards unaerated areas of the lungs which may lead to a ventilation/perfusion mismatch even at minor cases of COVID-19. The results also suggest that subject-specific regulated use of vasodilating medication may reduce the number of cases that require mechanical ventilation.},
   issn = {2088-5334},
   publisher = {INSIGHT - Indonesian Society for Knowledge and Human Development},
   url = {http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=12579},
   doi = {10.18517/ijaseit.12.3.12579}
}

EndNote

%A Ibrahim, Gihad
%A Hassan, Ahmed
%D 2022
%T CT-based Analysis of Vascular Tree Abnormalities in Different Phenotypes of COVID-19 Pneumonia
%B 2022
%9 COVID-19 pneumonia; SARS-CoV-2; COVID-19 phenotypes; vascular tree analysis.
%! CT-based Analysis of Vascular Tree Abnormalities in Different Phenotypes of COVID-19 Pneumonia
%K COVID-19 pneumonia; SARS-CoV-2; COVID-19 phenotypes; vascular tree analysis.
%X In this paper, Computed Tomography (CT) images of six confirmed COVID-19 patients were analyzed in order to investigate the physiological abnormalities in the vascular tree in response to the disease-induced hypoxia. The CT images were classified into an L-type and H-type groups based on the cumulative voxel distribution of the CT scan. A 3-Dimentional model of the vascular tree was reconstructed out of each CT image following a computational framework. Then, the Cross-Sectional Area (CSA) of the vessels belonging to each vascular tree was computed. The acquired results were compared against averaged measurements of three healthy subjects that were computed following the same approach. The results showed that as the severity of COVID-19 lean towards H-type phenotype, signs of vasoconstriction in small blood vessels with a CSA less than 10 mm2 tend to decreases, whereas signs of vasodilation in medium to large blood vessels increases. The intensity of dilated blood vessels proximal to consolidated areas of the lung was found to increase significantly as the disease progresses in the lungs. Furthermore, signs of vasoconstriction and vasodilation in the vascular tree were observed in all lobes of the lung in both phenotypes including seemingly healthy lobes. The results in this paper are suggestive of intrapulmonary blood flow shunting towards unaerated areas of the lungs which may lead to a ventilation/perfusion mismatch even at minor cases of COVID-19. The results also suggest that subject-specific regulated use of vasodilating medication may reduce the number of cases that require mechanical ventilation.
%U http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=12579
%R doi:10.18517/ijaseit.12.3.12579
%J International Journal on Advanced Science, Engineering and Information Technology
%V 12
%N 3
%@ 2088-5334

IEEE

Gihad Ibrahim and Ahmed Hassan,"CT-based Analysis of Vascular Tree Abnormalities in Different Phenotypes of COVID-19 Pneumonia," International Journal on Advanced Science, Engineering and Information Technology, vol. 12, no. 3, pp. 1215-1221, 2022. [Online]. Available: http://dx.doi.org/10.18517/ijaseit.12.3.12579.

RefMan/ProCite (RIS)

TY  - JOUR
AU  - Ibrahim, Gihad
AU  - Hassan, Ahmed
PY  - 2022
TI  - CT-based Analysis of Vascular Tree Abnormalities in Different Phenotypes of COVID-19 Pneumonia
JF  - International Journal on Advanced Science, Engineering and Information Technology; Vol. 12 (2022) No. 3
Y2  - 2022
SP  - 1215
EP  - 1221
SN  - 2088-5334
PB  - INSIGHT - Indonesian Society for Knowledge and Human Development
KW  - COVID-19 pneumonia; SARS-CoV-2; COVID-19 phenotypes; vascular tree analysis.
N2  - In this paper, Computed Tomography (CT) images of six confirmed COVID-19 patients were analyzed in order to investigate the physiological abnormalities in the vascular tree in response to the disease-induced hypoxia. The CT images were classified into an L-type and H-type groups based on the cumulative voxel distribution of the CT scan. A 3-Dimentional model of the vascular tree was reconstructed out of each CT image following a computational framework. Then, the Cross-Sectional Area (CSA) of the vessels belonging to each vascular tree was computed. The acquired results were compared against averaged measurements of three healthy subjects that were computed following the same approach. The results showed that as the severity of COVID-19 lean towards H-type phenotype, signs of vasoconstriction in small blood vessels with a CSA less than 10 mm2 tend to decreases, whereas signs of vasodilation in medium to large blood vessels increases. The intensity of dilated blood vessels proximal to consolidated areas of the lung was found to increase significantly as the disease progresses in the lungs. Furthermore, signs of vasoconstriction and vasodilation in the vascular tree were observed in all lobes of the lung in both phenotypes including seemingly healthy lobes. The results in this paper are suggestive of intrapulmonary blood flow shunting towards unaerated areas of the lungs which may lead to a ventilation/perfusion mismatch even at minor cases of COVID-19. The results also suggest that subject-specific regulated use of vasodilating medication may reduce the number of cases that require mechanical ventilation.
UR  - http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=12579
DO  - 10.18517/ijaseit.12.3.12579

RefWorks

RT Journal Article
ID 12579
A1 Ibrahim, Gihad
A1 Hassan, Ahmed
T1 CT-based Analysis of Vascular Tree Abnormalities in Different Phenotypes of COVID-19 Pneumonia
JF International Journal on Advanced Science, Engineering and Information Technology
VO 12
IS 3
YR 2022
SP 1215
OP 1221
SN 2088-5334
PB INSIGHT - Indonesian Society for Knowledge and Human Development
K1 COVID-19 pneumonia; SARS-CoV-2; COVID-19 phenotypes; vascular tree analysis.
AB In this paper, Computed Tomography (CT) images of six confirmed COVID-19 patients were analyzed in order to investigate the physiological abnormalities in the vascular tree in response to the disease-induced hypoxia. The CT images were classified into an L-type and H-type groups based on the cumulative voxel distribution of the CT scan. A 3-Dimentional model of the vascular tree was reconstructed out of each CT image following a computational framework. Then, the Cross-Sectional Area (CSA) of the vessels belonging to each vascular tree was computed. The acquired results were compared against averaged measurements of three healthy subjects that were computed following the same approach. The results showed that as the severity of COVID-19 lean towards H-type phenotype, signs of vasoconstriction in small blood vessels with a CSA less than 10 mm2 tend to decreases, whereas signs of vasodilation in medium to large blood vessels increases. The intensity of dilated blood vessels proximal to consolidated areas of the lung was found to increase significantly as the disease progresses in the lungs. Furthermore, signs of vasoconstriction and vasodilation in the vascular tree were observed in all lobes of the lung in both phenotypes including seemingly healthy lobes. The results in this paper are suggestive of intrapulmonary blood flow shunting towards unaerated areas of the lungs which may lead to a ventilation/perfusion mismatch even at minor cases of COVID-19. The results also suggest that subject-specific regulated use of vasodilating medication may reduce the number of cases that require mechanical ventilation.
LK http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=12579
DO  - 10.18517/ijaseit.12.3.12579