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The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process in Acidic Medium

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@article{IJASEIT2463,
   author = {Meri Yulvianti and Jayanudin Jayanudin and Rochmadi Rochmadi and Ajeng Risalina},
   title = {The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process  in Acidic Medium},
   journal = {International Journal on Advanced Science, Engineering and Information Technology},
   volume = {7},
   number = {5},
   year = {2017},
   pages = {1900--1906},
   keywords = {micro-particle; chitosan-alginate; tri poly phosphate; spray dryer},
   abstract = {Chitosan-Alginate micro-particles can serve as coating to the drug through the encapsulation process for controlled release. The addition of Tri Poly Phosphate would change the characterization of Chitosan-Alginate micro-particles because of the process of cross linking. This study aims to determine the characterization of micro-particles of Chitosan-Alginate based on particle size distribution, particle surface morphology and dissolution process in acid medium. The method used to make micro-particles of Chitosan-Alginate is using spray drying, thus the micro-particles can be made by mixing Chitosan-Alginate with a weight ratio of 1: 1, 1: 2, 2: 1 then mixed the crosslinking compound Tri Poly Phosphate (TPP) with a concentration of 0.1%, 0.3%, 0.5%, and added emulsifier Tween 80 3% v / v, stirred at a speed of 20,000 rpm for 10 minutes then inserted into the spray dryer to form micro-particles. The powder of micro-particles then analysed by Scanning Electron Microscopy (SEM) and performed in vitro of stomach acid solution using acidic medium for the test of dissolution. Based on the research that has been done, 0.1% TPP concentration of Chitosan-Alginate ratio of 2: 1 can produce the most uniform size distribution with a ratio of 40.54%. The biggest dissolution of micro-particles obtained from the samples with Chitosan-Alginate ratio of 2: 1 with a concentration of 0.1% TPP was 80.8%.},
   issn = {2088-5334},
   publisher = {INSIGHT - Indonesian Society for Knowledge and Human Development},
   url = {http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=2463},
   doi = {10.18517/ijaseit.7.5.2463}
}

EndNote

%A Yulvianti, Meri
%A Jayanudin, Jayanudin
%A Rochmadi, Rochmadi
%A Risalina, Ajeng
%D 2017
%T The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process  in Acidic Medium
%B 2017
%9 micro-particle; chitosan-alginate; tri poly phosphate; spray dryer
%! The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process  in Acidic Medium
%K micro-particle; chitosan-alginate; tri poly phosphate; spray dryer
%X Chitosan-Alginate micro-particles can serve as coating to the drug through the encapsulation process for controlled release. The addition of Tri Poly Phosphate would change the characterization of Chitosan-Alginate micro-particles because of the process of cross linking. This study aims to determine the characterization of micro-particles of Chitosan-Alginate based on particle size distribution, particle surface morphology and dissolution process in acid medium. The method used to make micro-particles of Chitosan-Alginate is using spray drying, thus the micro-particles can be made by mixing Chitosan-Alginate with a weight ratio of 1: 1, 1: 2, 2: 1 then mixed the crosslinking compound Tri Poly Phosphate (TPP) with a concentration of 0.1%, 0.3%, 0.5%, and added emulsifier Tween 80 3% v / v, stirred at a speed of 20,000 rpm for 10 minutes then inserted into the spray dryer to form micro-particles. The powder of micro-particles then analysed by Scanning Electron Microscopy (SEM) and performed in vitro of stomach acid solution using acidic medium for the test of dissolution. Based on the research that has been done, 0.1% TPP concentration of Chitosan-Alginate ratio of 2: 1 can produce the most uniform size distribution with a ratio of 40.54%. The biggest dissolution of micro-particles obtained from the samples with Chitosan-Alginate ratio of 2: 1 with a concentration of 0.1% TPP was 80.8%.
%U http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=2463
%R doi:10.18517/ijaseit.7.5.2463
%J International Journal on Advanced Science, Engineering and Information Technology
%V 7
%N 5
%@ 2088-5334

IEEE

Meri Yulvianti,Jayanudin Jayanudin,Rochmadi Rochmadi and Ajeng Risalina,"The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process  in Acidic Medium," International Journal on Advanced Science, Engineering and Information Technology, vol. 7, no. 5, pp. 1900-1906, 2017. [Online]. Available: http://dx.doi.org/10.18517/ijaseit.7.5.2463.

RefMan/ProCite (RIS)

TY  - JOUR
AU  - Yulvianti, Meri
AU  - Jayanudin, Jayanudin
AU  - Rochmadi, Rochmadi
AU  - Risalina, Ajeng
PY  - 2017
TI  - The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process  in Acidic Medium
JF  - International Journal on Advanced Science, Engineering and Information Technology; Vol. 7 (2017) No. 5
Y2  - 2017
SP  - 1900
EP  - 1906
SN  - 2088-5334
PB  - INSIGHT - Indonesian Society for Knowledge and Human Development
KW  - micro-particle; chitosan-alginate; tri poly phosphate; spray dryer
N2  - Chitosan-Alginate micro-particles can serve as coating to the drug through the encapsulation process for controlled release. The addition of Tri Poly Phosphate would change the characterization of Chitosan-Alginate micro-particles because of the process of cross linking. This study aims to determine the characterization of micro-particles of Chitosan-Alginate based on particle size distribution, particle surface morphology and dissolution process in acid medium. The method used to make micro-particles of Chitosan-Alginate is using spray drying, thus the micro-particles can be made by mixing Chitosan-Alginate with a weight ratio of 1: 1, 1: 2, 2: 1 then mixed the crosslinking compound Tri Poly Phosphate (TPP) with a concentration of 0.1%, 0.3%, 0.5%, and added emulsifier Tween 80 3% v / v, stirred at a speed of 20,000 rpm for 10 minutes then inserted into the spray dryer to form micro-particles. The powder of micro-particles then analysed by Scanning Electron Microscopy (SEM) and performed in vitro of stomach acid solution using acidic medium for the test of dissolution. Based on the research that has been done, 0.1% TPP concentration of Chitosan-Alginate ratio of 2: 1 can produce the most uniform size distribution with a ratio of 40.54%. The biggest dissolution of micro-particles obtained from the samples with Chitosan-Alginate ratio of 2: 1 with a concentration of 0.1% TPP was 80.8%.
UR  - http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=2463
DO  - 10.18517/ijaseit.7.5.2463

RefWorks

RT Journal Article
ID 2463
A1 Yulvianti, Meri
A1 Jayanudin, Jayanudin
A1 Rochmadi, Rochmadi
A1 Risalina, Ajeng
T1 The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process  in Acidic Medium
JF International Journal on Advanced Science, Engineering and Information Technology
VO 7
IS 5
YR 2017
SP 1900
OP 1906
SN 2088-5334
PB INSIGHT - Indonesian Society for Knowledge and Human Development
K1 micro-particle; chitosan-alginate; tri poly phosphate; spray dryer
AB Chitosan-Alginate micro-particles can serve as coating to the drug through the encapsulation process for controlled release. The addition of Tri Poly Phosphate would change the characterization of Chitosan-Alginate micro-particles because of the process of cross linking. This study aims to determine the characterization of micro-particles of Chitosan-Alginate based on particle size distribution, particle surface morphology and dissolution process in acid medium. The method used to make micro-particles of Chitosan-Alginate is using spray drying, thus the micro-particles can be made by mixing Chitosan-Alginate with a weight ratio of 1: 1, 1: 2, 2: 1 then mixed the crosslinking compound Tri Poly Phosphate (TPP) with a concentration of 0.1%, 0.3%, 0.5%, and added emulsifier Tween 80 3% v / v, stirred at a speed of 20,000 rpm for 10 minutes then inserted into the spray dryer to form micro-particles. The powder of micro-particles then analysed by Scanning Electron Microscopy (SEM) and performed in vitro of stomach acid solution using acidic medium for the test of dissolution. Based on the research that has been done, 0.1% TPP concentration of Chitosan-Alginate ratio of 2: 1 can produce the most uniform size distribution with a ratio of 40.54%. The biggest dissolution of micro-particles obtained from the samples with Chitosan-Alginate ratio of 2: 1 with a concentration of 0.1% TPP was 80.8%.
LK http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=2463
DO  - 10.18517/ijaseit.7.5.2463