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Agarwood Leaf Essential Oil Characterization and Effects on MCF-7 Breast Cancer Cells

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@article{IJASEIT7034,
   author = {Nur A. A. Zainurin and Yumi Z. H Y. Hashim and Nor F. Mohamed Azmin and Phirdaous Abbas},
   title = {Agarwood Leaf Essential Oil Characterization and Effects on MCF-7 Breast Cancer Cells},
   journal = {International Journal on Advanced Science, Engineering and Information Technology},
   volume = {8},
   number = {4-2},
   year = {2018},
   pages = {1604--1609},
   keywords = {Agarwood leaf; breast cancer; essential oil; GCMS; MCF-7.},
   abstract = {

Breast cancer continues to remain as the leading cause of cancer mortality among women worldwide. Agents for prevention and cure for breast cancer are contiuously being researched. İn particular, agarwood essential oil from resin infiltrated heartwood has been reported to have substantial evidences of medicinal benefits. Nevertheless, there is very limited report on agarwood leaf essential oil (ALEO). Hence, this present study was conducted to evaluate the physicochemical properties, chemical constituents and anticancer activity of ALEO. ALEO was observed to be of pale-yellow colour with sweet smell. Other physicochemical properties include refractive index of 1.44, specific gravity of 0.886, saponification value of 131.88 mg KOH/g, acid value of 2.80 mg KOH/g and iodine value of 105.07 gI2/100g. The profiling of chemical constituents using gas chromatography-mass spectrometry (GCMS) revealed 19 compounds. Hexadecanoic acid was the major compound (64.41%). The biomarkers of agarwood; azulene (0.619%) and guaiol (0.2997%) were also detected. ALEO was tested for anticancer activity against MCF-7 cancer cells using WST-8 assay. ALEO showed the IC50 value of 31% (v/v) against MCF-7 cells after 36 hours of treatment. In conclusion, this study provides information on ALEO physicochemical properties and chemical constituents that can be used as benchmark for quality assurance as well as proof that ALEO holds a potential as anticancer agent.

},    issn = {2088-5334},    publisher = {INSIGHT - Indonesian Society for Knowledge and Human Development},    url = {http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7034},    doi = {10.18517/ijaseit.8.4-2.7034} }

EndNote

%A Zainurin, Nur A. A.
%A Hashim, Yumi Z. H Y.
%A Azmin, Nor F. Mohamed
%A Abbas, Phirdaous
%D 2018
%T Agarwood Leaf Essential Oil Characterization and Effects on MCF-7 Breast Cancer Cells
%B 2018
%9 Agarwood leaf; breast cancer; essential oil; GCMS; MCF-7.
%! Agarwood Leaf Essential Oil Characterization and Effects on MCF-7 Breast Cancer Cells
%K Agarwood leaf; breast cancer; essential oil; GCMS; MCF-7.
%X 

Breast cancer continues to remain as the leading cause of cancer mortality among women worldwide. Agents for prevention and cure for breast cancer are contiuously being researched. İn particular, agarwood essential oil from resin infiltrated heartwood has been reported to have substantial evidences of medicinal benefits. Nevertheless, there is very limited report on agarwood leaf essential oil (ALEO). Hence, this present study was conducted to evaluate the physicochemical properties, chemical constituents and anticancer activity of ALEO. ALEO was observed to be of pale-yellow colour with sweet smell. Other physicochemical properties include refractive index of 1.44, specific gravity of 0.886, saponification value of 131.88 mg KOH/g, acid value of 2.80 mg KOH/g and iodine value of 105.07 gI2/100g. The profiling of chemical constituents using gas chromatography-mass spectrometry (GCMS) revealed 19 compounds. Hexadecanoic acid was the major compound (64.41%). The biomarkers of agarwood; azulene (0.619%) and guaiol (0.2997%) were also detected. ALEO was tested for anticancer activity against MCF-7 cancer cells using WST-8 assay. ALEO showed the IC50 value of 31% (v/v) against MCF-7 cells after 36 hours of treatment. In conclusion, this study provides information on ALEO physicochemical properties and chemical constituents that can be used as benchmark for quality assurance as well as proof that ALEO holds a potential as anticancer agent.

%U http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7034 %R doi:10.18517/ijaseit.8.4-2.7034 %J International Journal on Advanced Science, Engineering and Information Technology %V 8 %N 4-2 %@ 2088-5334

IEEE

Nur A. A. Zainurin,Yumi Z. H Y. Hashim,Nor F. Mohamed Azmin and Phirdaous Abbas,"Agarwood Leaf Essential Oil Characterization and Effects on MCF-7 Breast Cancer Cells," International Journal on Advanced Science, Engineering and Information Technology, vol. 8, no. 4-2, pp. 1604-1609, 2018. [Online]. Available: http://dx.doi.org/10.18517/ijaseit.8.4-2.7034.

RefMan/ProCite (RIS)

TY  - JOUR
AU  - Zainurin, Nur A. A.
AU  - Hashim, Yumi Z. H Y.
AU  - Azmin, Nor F. Mohamed
AU  - Abbas, Phirdaous
PY  - 2018
TI  - Agarwood Leaf Essential Oil Characterization and Effects on MCF-7 Breast Cancer Cells
JF  - International Journal on Advanced Science, Engineering and Information Technology; Vol. 8 (2018) No. 4-2
Y2  - 2018
SP  - 1604
EP  - 1609
SN  - 2088-5334
PB  - INSIGHT - Indonesian Society for Knowledge and Human Development
KW  - Agarwood leaf; breast cancer; essential oil; GCMS; MCF-7.
N2  - 

Breast cancer continues to remain as the leading cause of cancer mortality among women worldwide. Agents for prevention and cure for breast cancer are contiuously being researched. İn particular, agarwood essential oil from resin infiltrated heartwood has been reported to have substantial evidences of medicinal benefits. Nevertheless, there is very limited report on agarwood leaf essential oil (ALEO). Hence, this present study was conducted to evaluate the physicochemical properties, chemical constituents and anticancer activity of ALEO. ALEO was observed to be of pale-yellow colour with sweet smell. Other physicochemical properties include refractive index of 1.44, specific gravity of 0.886, saponification value of 131.88 mg KOH/g, acid value of 2.80 mg KOH/g and iodine value of 105.07 gI2/100g. The profiling of chemical constituents using gas chromatography-mass spectrometry (GCMS) revealed 19 compounds. Hexadecanoic acid was the major compound (64.41%). The biomarkers of agarwood; azulene (0.619%) and guaiol (0.2997%) were also detected. ALEO was tested for anticancer activity against MCF-7 cancer cells using WST-8 assay. ALEO showed the IC50 value of 31% (v/v) against MCF-7 cells after 36 hours of treatment. In conclusion, this study provides information on ALEO physicochemical properties and chemical constituents that can be used as benchmark for quality assurance as well as proof that ALEO holds a potential as anticancer agent.

UR - http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7034 DO - 10.18517/ijaseit.8.4-2.7034

RefWorks

RT Journal Article
ID 7034
A1 Zainurin, Nur A. A.
A1 Hashim, Yumi Z. H Y.
A1 Azmin, Nor F. Mohamed
A1 Abbas, Phirdaous
T1 Agarwood Leaf Essential Oil Characterization and Effects on MCF-7 Breast Cancer Cells
JF International Journal on Advanced Science, Engineering and Information Technology
VO 8
IS 4-2
YR 2018
SP 1604
OP 1609
SN 2088-5334
PB INSIGHT - Indonesian Society for Knowledge and Human Development
K1 Agarwood leaf; breast cancer; essential oil; GCMS; MCF-7.
AB 

Breast cancer continues to remain as the leading cause of cancer mortality among women worldwide. Agents for prevention and cure for breast cancer are contiuously being researched. İn particular, agarwood essential oil from resin infiltrated heartwood has been reported to have substantial evidences of medicinal benefits. Nevertheless, there is very limited report on agarwood leaf essential oil (ALEO). Hence, this present study was conducted to evaluate the physicochemical properties, chemical constituents and anticancer activity of ALEO. ALEO was observed to be of pale-yellow colour with sweet smell. Other physicochemical properties include refractive index of 1.44, specific gravity of 0.886, saponification value of 131.88 mg KOH/g, acid value of 2.80 mg KOH/g and iodine value of 105.07 gI2/100g. The profiling of chemical constituents using gas chromatography-mass spectrometry (GCMS) revealed 19 compounds. Hexadecanoic acid was the major compound (64.41%). The biomarkers of agarwood; azulene (0.619%) and guaiol (0.2997%) were also detected. ALEO was tested for anticancer activity against MCF-7 cancer cells using WST-8 assay. ALEO showed the IC50 value of 31% (v/v) against MCF-7 cells after 36 hours of treatment. In conclusion, this study provides information on ALEO physicochemical properties and chemical constituents that can be used as benchmark for quality assurance as well as proof that ALEO holds a potential as anticancer agent.

LK http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7034 DO - 10.18517/ijaseit.8.4-2.7034