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Aquilaria malaccensis Leaf as an Alternative Source of Anti-inflammatory Compounds

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@article{IJASEIT7054,
   author = {Manar Eissa and Yumi Z. H Y. Hashim and Nur Aimi A. Zainurin},
   title = {Aquilaria malaccensis Leaf as an Alternative Source of Anti-inflammatory Compounds},
   journal = {International Journal on Advanced Science, Engineering and Information Technology},
   volume = {8},
   number = {4-2},
   year = {2018},
   pages = {1625--1632},
   keywords = {anti-inflammatory; Aquilaria malaccensis; halal; SFE;  soxhlet},
   abstract = {Currently, the long-term consumption of aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory medicines and pain relievers, have been reported to cause various side effects. Thus, natural compounds of several plant species including Aquilaria malaccensis have been explored as an alternative therapeutic source for inflammation treatment with regard to their safety and efficacy. Despite the accelerating rate on the research of agarwood leaf, the scientific evidences to elucidate the proclaimed pharmacological activities particularly anti-inflammatory activity are still limited. Therefore, it is the interest of this study to investigate the biological activity relating to the anti-inflammatory activity of A. malaccensis leaf extracted using Soxhlet and Supercritical Fluid Extraction (SFE) methods. Results showed that A. malaccensis leaf ethanolic soxhlet extract (ALEXB) gave higher yield (mg/g) of 98.33 ± 4.11 (9.83% wt/wt) as compared to soxhlet extract using hexane (ALEXA); 24.04 ± 5.27 (2.40% wt/wt) after 6 hours of extraction. Meanwhile, the supercritical fluid extract (SFEX) gave a relatively low yield of 12.57 ± 0.61 (1.26% wt/wt). The GCMS analysis revealed that 25, 30 and 16 compounds were detected in ALEXA, ALEXB and SFEX respectively with phytol as the major compound in the soxhlet extracts and n-hexadecanoic as a major compound in SFEX. Subsequently, in-vitro study showed that the extracts demonstrated inhibition of protein (albumin) denaturation in a concentration-dependent manner throughout a concentration range of 400-16000 µg/ml tested. Exclusively, the GCMS of leaf SFEX showed a peak of 1H-Cycloprop[e]azulene, decahydro-1,1,7-trimethyl-4-methylene (0.4205%), a tricyclic sesquiterpene that was testified to have potential analgesic and anti-inflammatory activity. Further research is warranted to explore the anti-inflammatory activities of A. malaccensis leaf extracts and their mechanism of action as an alternative halal ingredient for nutraceuticals and pharmaceuticals.},
   issn = {2088-5334},
   publisher = {INSIGHT - Indonesian Society for Knowledge and Human Development},
   url = {http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7054},
   doi = {10.18517/ijaseit.8.4-2.7054}
}

EndNote

%A Eissa, Manar
%A Hashim, Yumi Z. H Y.
%A Zainurin, Nur Aimi A.
%D 2018
%T Aquilaria malaccensis Leaf as an Alternative Source of Anti-inflammatory Compounds
%B 2018
%9 anti-inflammatory; Aquilaria malaccensis; halal; SFE;  soxhlet
%! Aquilaria malaccensis Leaf as an Alternative Source of Anti-inflammatory Compounds
%K anti-inflammatory; Aquilaria malaccensis; halal; SFE;  soxhlet
%X Currently, the long-term consumption of aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory medicines and pain relievers, have been reported to cause various side effects. Thus, natural compounds of several plant species including Aquilaria malaccensis have been explored as an alternative therapeutic source for inflammation treatment with regard to their safety and efficacy. Despite the accelerating rate on the research of agarwood leaf, the scientific evidences to elucidate the proclaimed pharmacological activities particularly anti-inflammatory activity are still limited. Therefore, it is the interest of this study to investigate the biological activity relating to the anti-inflammatory activity of A. malaccensis leaf extracted using Soxhlet and Supercritical Fluid Extraction (SFE) methods. Results showed that A. malaccensis leaf ethanolic soxhlet extract (ALEXB) gave higher yield (mg/g) of 98.33 ± 4.11 (9.83% wt/wt) as compared to soxhlet extract using hexane (ALEXA); 24.04 ± 5.27 (2.40% wt/wt) after 6 hours of extraction. Meanwhile, the supercritical fluid extract (SFEX) gave a relatively low yield of 12.57 ± 0.61 (1.26% wt/wt). The GCMS analysis revealed that 25, 30 and 16 compounds were detected in ALEXA, ALEXB and SFEX respectively with phytol as the major compound in the soxhlet extracts and n-hexadecanoic as a major compound in SFEX. Subsequently, in-vitro study showed that the extracts demonstrated inhibition of protein (albumin) denaturation in a concentration-dependent manner throughout a concentration range of 400-16000 µg/ml tested. Exclusively, the GCMS of leaf SFEX showed a peak of 1H-Cycloprop[e]azulene, decahydro-1,1,7-trimethyl-4-methylene (0.4205%), a tricyclic sesquiterpene that was testified to have potential analgesic and anti-inflammatory activity. Further research is warranted to explore the anti-inflammatory activities of A. malaccensis leaf extracts and their mechanism of action as an alternative halal ingredient for nutraceuticals and pharmaceuticals.
%U http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7054
%R doi:10.18517/ijaseit.8.4-2.7054
%J International Journal on Advanced Science, Engineering and Information Technology
%V 8
%N 4-2
%@ 2088-5334

IEEE

Manar Eissa,Yumi Z. H Y. Hashim and Nur Aimi A. Zainurin,"Aquilaria malaccensis Leaf as an Alternative Source of Anti-inflammatory Compounds," International Journal on Advanced Science, Engineering and Information Technology, vol. 8, no. 4-2, pp. 1625-1632, 2018. [Online]. Available: http://dx.doi.org/10.18517/ijaseit.8.4-2.7054.

RefMan/ProCite (RIS)

TY  - JOUR
AU  - Eissa, Manar
AU  - Hashim, Yumi Z. H Y.
AU  - Zainurin, Nur Aimi A.
PY  - 2018
TI  - Aquilaria malaccensis Leaf as an Alternative Source of Anti-inflammatory Compounds
JF  - International Journal on Advanced Science, Engineering and Information Technology; Vol. 8 (2018) No. 4-2
Y2  - 2018
SP  - 1625
EP  - 1632
SN  - 2088-5334
PB  - INSIGHT - Indonesian Society for Knowledge and Human Development
KW  - anti-inflammatory; Aquilaria malaccensis; halal; SFE;  soxhlet
N2  - Currently, the long-term consumption of aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory medicines and pain relievers, have been reported to cause various side effects. Thus, natural compounds of several plant species including Aquilaria malaccensis have been explored as an alternative therapeutic source for inflammation treatment with regard to their safety and efficacy. Despite the accelerating rate on the research of agarwood leaf, the scientific evidences to elucidate the proclaimed pharmacological activities particularly anti-inflammatory activity are still limited. Therefore, it is the interest of this study to investigate the biological activity relating to the anti-inflammatory activity of A. malaccensis leaf extracted using Soxhlet and Supercritical Fluid Extraction (SFE) methods. Results showed that A. malaccensis leaf ethanolic soxhlet extract (ALEXB) gave higher yield (mg/g) of 98.33 ± 4.11 (9.83% wt/wt) as compared to soxhlet extract using hexane (ALEXA); 24.04 ± 5.27 (2.40% wt/wt) after 6 hours of extraction. Meanwhile, the supercritical fluid extract (SFEX) gave a relatively low yield of 12.57 ± 0.61 (1.26% wt/wt). The GCMS analysis revealed that 25, 30 and 16 compounds were detected in ALEXA, ALEXB and SFEX respectively with phytol as the major compound in the soxhlet extracts and n-hexadecanoic as a major compound in SFEX. Subsequently, in-vitro study showed that the extracts demonstrated inhibition of protein (albumin) denaturation in a concentration-dependent manner throughout a concentration range of 400-16000 µg/ml tested. Exclusively, the GCMS of leaf SFEX showed a peak of 1H-Cycloprop[e]azulene, decahydro-1,1,7-trimethyl-4-methylene (0.4205%), a tricyclic sesquiterpene that was testified to have potential analgesic and anti-inflammatory activity. Further research is warranted to explore the anti-inflammatory activities of A. malaccensis leaf extracts and their mechanism of action as an alternative halal ingredient for nutraceuticals and pharmaceuticals.
UR  - http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7054
DO  - 10.18517/ijaseit.8.4-2.7054

RefWorks

RT Journal Article
ID 7054
A1 Eissa, Manar
A1 Hashim, Yumi Z. H Y.
A1 Zainurin, Nur Aimi A.
T1 Aquilaria malaccensis Leaf as an Alternative Source of Anti-inflammatory Compounds
JF International Journal on Advanced Science, Engineering and Information Technology
VO 8
IS 4-2
YR 2018
SP 1625
OP 1632
SN 2088-5334
PB INSIGHT - Indonesian Society for Knowledge and Human Development
K1 anti-inflammatory; Aquilaria malaccensis; halal; SFE;  soxhlet
AB Currently, the long-term consumption of aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory medicines and pain relievers, have been reported to cause various side effects. Thus, natural compounds of several plant species including Aquilaria malaccensis have been explored as an alternative therapeutic source for inflammation treatment with regard to their safety and efficacy. Despite the accelerating rate on the research of agarwood leaf, the scientific evidences to elucidate the proclaimed pharmacological activities particularly anti-inflammatory activity are still limited. Therefore, it is the interest of this study to investigate the biological activity relating to the anti-inflammatory activity of A. malaccensis leaf extracted using Soxhlet and Supercritical Fluid Extraction (SFE) methods. Results showed that A. malaccensis leaf ethanolic soxhlet extract (ALEXB) gave higher yield (mg/g) of 98.33 ± 4.11 (9.83% wt/wt) as compared to soxhlet extract using hexane (ALEXA); 24.04 ± 5.27 (2.40% wt/wt) after 6 hours of extraction. Meanwhile, the supercritical fluid extract (SFEX) gave a relatively low yield of 12.57 ± 0.61 (1.26% wt/wt). The GCMS analysis revealed that 25, 30 and 16 compounds were detected in ALEXA, ALEXB and SFEX respectively with phytol as the major compound in the soxhlet extracts and n-hexadecanoic as a major compound in SFEX. Subsequently, in-vitro study showed that the extracts demonstrated inhibition of protein (albumin) denaturation in a concentration-dependent manner throughout a concentration range of 400-16000 µg/ml tested. Exclusively, the GCMS of leaf SFEX showed a peak of 1H-Cycloprop[e]azulene, decahydro-1,1,7-trimethyl-4-methylene (0.4205%), a tricyclic sesquiterpene that was testified to have potential analgesic and anti-inflammatory activity. Further research is warranted to explore the anti-inflammatory activities of A. malaccensis leaf extracts and their mechanism of action as an alternative halal ingredient for nutraceuticals and pharmaceuticals.
LK http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=7054
DO  - 10.18517/ijaseit.8.4-2.7054