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Stimulating Activity on Human Lymphocytes in vitro of Nori like Product (Geluring) Made from Gelidium sp. and Ulva lactuca Seaweeds

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@article{IJASEIT9440,
   author = {- Erniati and Fransiska Zakaria Rungkat and Endang Prangdimurti and Dede Robiatul Adawiyah and Bambang Pontjo Priosoeryanto and Nurul Huda},
   title = {Stimulating Activity on Human Lymphocytes in vitro  of Nori like Product (Geluring) Made from Gelidium sp. and Ulva lactuca Seaweeds},
   journal = {International Journal on Advanced Science, Engineering and Information Technology},
   volume = {10},
   number = {3},
   year = {2020},
   pages = {1311--1316},
   keywords = {immune system; interleukin-2; lymphocytes proliferation; geluring; seaweed.},
   abstract = {Seaweed has been reported to contain bioactive compounds that have an immunomodulatory activity, such as stimulating activity on human lymphocytes. Nori like the product from the mixture of Gelidium sp. and Ulva lactuca seaweed in this research named “geluring” may improve the immune system. This research is aimed to determine the stimulating activity of geluring by observing proliferation activity and interleukin-2 (IL-2) production of human lymphocyte by in vitro method. Two types of geluring were prepared, that were P1 (unseasoned geluring) and P2 (seasoned geluring) according to the commercial nori process with some modification. Gelurings were extracted with water and the extracts were added into lymphocyte cultures with various concentrations. The results showed that extracts of P1 and P2 gelurings could stimulate lymphocyte proliferation and IL-2 production significantly (P<0.05) compared with the stimulations demonstrated by the  cultures stimulated with PHA, RPMI, and extracts of unprocessed dried Ulva lactuca (UP0) but not significantly as compare to cultures added with unprocessed dried Gelidium sp.(GP0). Moreover, P2 geluring showed stimulation of lymphocyte proliferation and IL-2 production higher than P1 geluring and those of the control cultures. There was a positive correlation of proliferative activity with IL-2 production of the lymphocytes. The stimulation of lymphocyte proliferation and IL-2 production by P1 and P2 gelurings was significantly influenced by the concentration of the extracts. The concentration of 2.66 mg/ml culture showed the highest proliferation and IL-2 production of the cells. Base on this research, it can be concluded that geluring products made from the mixture of Gelidium sp. and Ulva lactuca stimulate the activity of lymphocytes, which indicates the potential to be used as a health food to improve the immune system.},
   issn = {2088-5334},
   publisher = {INSIGHT - Indonesian Society for Knowledge and Human Development},
   url = {http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=9440},
   doi = {10.18517/ijaseit.10.3.9440}
}

EndNote

%A Erniati, -
%A Rungkat, Fransiska Zakaria
%A Prangdimurti, Endang
%A Adawiyah, Dede Robiatul
%A Priosoeryanto, Bambang Pontjo
%A Huda, Nurul
%D 2020
%T Stimulating Activity on Human Lymphocytes in vitro  of Nori like Product (Geluring) Made from Gelidium sp. and Ulva lactuca Seaweeds
%B 2020
%9 immune system; interleukin-2; lymphocytes proliferation; geluring; seaweed.
%! Stimulating Activity on Human Lymphocytes in vitro  of Nori like Product (Geluring) Made from Gelidium sp. and Ulva lactuca Seaweeds
%K immune system; interleukin-2; lymphocytes proliferation; geluring; seaweed.
%X Seaweed has been reported to contain bioactive compounds that have an immunomodulatory activity, such as stimulating activity on human lymphocytes. Nori like the product from the mixture of Gelidium sp. and Ulva lactuca seaweed in this research named “geluring” may improve the immune system. This research is aimed to determine the stimulating activity of geluring by observing proliferation activity and interleukin-2 (IL-2) production of human lymphocyte by in vitro method. Two types of geluring were prepared, that were P1 (unseasoned geluring) and P2 (seasoned geluring) according to the commercial nori process with some modification. Gelurings were extracted with water and the extracts were added into lymphocyte cultures with various concentrations. The results showed that extracts of P1 and P2 gelurings could stimulate lymphocyte proliferation and IL-2 production significantly (P<0.05) compared with the stimulations demonstrated by the  cultures stimulated with PHA, RPMI, and extracts of unprocessed dried Ulva lactuca (UP0) but not significantly as compare to cultures added with unprocessed dried Gelidium sp.(GP0). Moreover, P2 geluring showed stimulation of lymphocyte proliferation and IL-2 production higher than P1 geluring and those of the control cultures. There was a positive correlation of proliferative activity with IL-2 production of the lymphocytes. The stimulation of lymphocyte proliferation and IL-2 production by P1 and P2 gelurings was significantly influenced by the concentration of the extracts. The concentration of 2.66 mg/ml culture showed the highest proliferation and IL-2 production of the cells. Base on this research, it can be concluded that geluring products made from the mixture of Gelidium sp. and Ulva lactuca stimulate the activity of lymphocytes, which indicates the potential to be used as a health food to improve the immune system.
%U http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=9440
%R doi:10.18517/ijaseit.10.3.9440
%J International Journal on Advanced Science, Engineering and Information Technology
%V 10
%N 3
%@ 2088-5334

IEEE

- Erniati,Fransiska Zakaria Rungkat,Endang Prangdimurti,Dede Robiatul Adawiyah,Bambang Pontjo Priosoeryanto and Nurul Huda,"Stimulating Activity on Human Lymphocytes in vitro  of Nori like Product (Geluring) Made from Gelidium sp. and Ulva lactuca Seaweeds," International Journal on Advanced Science, Engineering and Information Technology, vol. 10, no. 3, pp. 1311-1316, 2020. [Online]. Available: http://dx.doi.org/10.18517/ijaseit.10.3.9440.

RefMan/ProCite (RIS)

TY  - JOUR
AU  - Erniati, -
AU  - Rungkat, Fransiska Zakaria
AU  - Prangdimurti, Endang
AU  - Adawiyah, Dede Robiatul
AU  - Priosoeryanto, Bambang Pontjo
AU  - Huda, Nurul
PY  - 2020
TI  - Stimulating Activity on Human Lymphocytes in vitro  of Nori like Product (Geluring) Made from Gelidium sp. and Ulva lactuca Seaweeds
JF  - International Journal on Advanced Science, Engineering and Information Technology; Vol. 10 (2020) No. 3
Y2  - 2020
SP  - 1311
EP  - 1316
SN  - 2088-5334
PB  - INSIGHT - Indonesian Society for Knowledge and Human Development
KW  - immune system; interleukin-2; lymphocytes proliferation; geluring; seaweed.
N2  - Seaweed has been reported to contain bioactive compounds that have an immunomodulatory activity, such as stimulating activity on human lymphocytes. Nori like the product from the mixture of Gelidium sp. and Ulva lactuca seaweed in this research named “geluring” may improve the immune system. This research is aimed to determine the stimulating activity of geluring by observing proliferation activity and interleukin-2 (IL-2) production of human lymphocyte by in vitro method. Two types of geluring were prepared, that were P1 (unseasoned geluring) and P2 (seasoned geluring) according to the commercial nori process with some modification. Gelurings were extracted with water and the extracts were added into lymphocyte cultures with various concentrations. The results showed that extracts of P1 and P2 gelurings could stimulate lymphocyte proliferation and IL-2 production significantly (P<0.05) compared with the stimulations demonstrated by the  cultures stimulated with PHA, RPMI, and extracts of unprocessed dried Ulva lactuca (UP0) but not significantly as compare to cultures added with unprocessed dried Gelidium sp.(GP0). Moreover, P2 geluring showed stimulation of lymphocyte proliferation and IL-2 production higher than P1 geluring and those of the control cultures. There was a positive correlation of proliferative activity with IL-2 production of the lymphocytes. The stimulation of lymphocyte proliferation and IL-2 production by P1 and P2 gelurings was significantly influenced by the concentration of the extracts. The concentration of 2.66 mg/ml culture showed the highest proliferation and IL-2 production of the cells. Base on this research, it can be concluded that geluring products made from the mixture of Gelidium sp. and Ulva lactuca stimulate the activity of lymphocytes, which indicates the potential to be used as a health food to improve the immune system.
UR  - http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=9440
DO  - 10.18517/ijaseit.10.3.9440

RefWorks

RT Journal Article
ID 9440
A1 Erniati, -
A1 Rungkat, Fransiska Zakaria
A1 Prangdimurti, Endang
A1 Adawiyah, Dede Robiatul
A1 Priosoeryanto, Bambang Pontjo
A1 Huda, Nurul
T1 Stimulating Activity on Human Lymphocytes in vitro  of Nori like Product (Geluring) Made from Gelidium sp. and Ulva lactuca Seaweeds
JF International Journal on Advanced Science, Engineering and Information Technology
VO 10
IS 3
YR 2020
SP 1311
OP 1316
SN 2088-5334
PB INSIGHT - Indonesian Society for Knowledge and Human Development
K1 immune system; interleukin-2; lymphocytes proliferation; geluring; seaweed.
AB Seaweed has been reported to contain bioactive compounds that have an immunomodulatory activity, such as stimulating activity on human lymphocytes. Nori like the product from the mixture of Gelidium sp. and Ulva lactuca seaweed in this research named “geluring” may improve the immune system. This research is aimed to determine the stimulating activity of geluring by observing proliferation activity and interleukin-2 (IL-2) production of human lymphocyte by in vitro method. Two types of geluring were prepared, that were P1 (unseasoned geluring) and P2 (seasoned geluring) according to the commercial nori process with some modification. Gelurings were extracted with water and the extracts were added into lymphocyte cultures with various concentrations. The results showed that extracts of P1 and P2 gelurings could stimulate lymphocyte proliferation and IL-2 production significantly (P<0.05) compared with the stimulations demonstrated by the  cultures stimulated with PHA, RPMI, and extracts of unprocessed dried Ulva lactuca (UP0) but not significantly as compare to cultures added with unprocessed dried Gelidium sp.(GP0). Moreover, P2 geluring showed stimulation of lymphocyte proliferation and IL-2 production higher than P1 geluring and those of the control cultures. There was a positive correlation of proliferative activity with IL-2 production of the lymphocytes. The stimulation of lymphocyte proliferation and IL-2 production by P1 and P2 gelurings was significantly influenced by the concentration of the extracts. The concentration of 2.66 mg/ml culture showed the highest proliferation and IL-2 production of the cells. Base on this research, it can be concluded that geluring products made from the mixture of Gelidium sp. and Ulva lactuca stimulate the activity of lymphocytes, which indicates the potential to be used as a health food to improve the immune system.
LK http://ijaseit.insightsociety.org/index.php?option=com_content&view=article&id=9&Itemid=1&article_id=9440
DO  - 10.18517/ijaseit.10.3.9440