International Journal on Advanced Science, Engineering and Information Technology, Vol. 11 (2021) No. 5, pages: 1986-1992, DOI:10.18517/ijaseit.11.5.15999

No Correlation between Fagerstrom Test for Nicotine Dependence Scores to Lipopolysaccharide Marker in Thai Smokers

Parama Pratummas, Phakkharawat Sittiprapaporn, Chaiyavat Chaiyasut, Sasithorn Sirilun, Thamthiwat Nararatwanchai

Abstract

Cigarette smoking is a combination of thousands of synthetic compounds that contribute straightforwardly or by implication to the addiction of cigarette smoking with inflammation, although a lot more may exist. Genome-wide association studies (GWAS) have unequivocally shown that variety in neuronal nicotinic acetylcholine receptor subunit α5 (CHRNA5) and in cytochrome P450 2A6 (CYP2A6) anticipated smoking substantialness, later period of smoking discontinuance.The relationship between the Fagerstrom Test for Nicotine Dependence and the Lipopolysaccharide marker in Thai smokers was proposed in this study.We investigated fourteen Thai smokers in Mahasarakham province who scored 4 or higher on the Fagerstrom Test for Nicotine Dependence. We provided them surveys about their personal information, administered the Fagerstrom Test for Nicotine Dependence, and continued the Lipopolysaccharide marker blood tests. The value of R in Pearson connection was 0.4438. Although it found a positive correlation, the relationship between Fagerstrom Test for Nicotine Dependence and Lipopolysaccharide level was weak due to no correlation. In addition, the value of R2, the coefficient of determination, was 0.197 (p=0.1119). Further studies are needed to investigate more the relationship between smoking and inflammation.

Keywords:

Smokers; cigarette smoking; nicotine dependence; lipopolysaccharide; inflammation.

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