International Journal on Advanced Science, Engineering and Information Technology, Vol. 7 (2017) No. 5, DOI:10.18517/ijaseit.7.5.2463

The Effect of Tripolyphosphate Concentration towards Chitosan-Alginate Microparticle Characterization and Dissolution Process in Acidic Medium

Meri Yulvianti, Jayanudin Jayanudin, Rochmadi Rochmadi, Ajeng Risalina

Abstract

Chitosan-Alginate microparticles can serve as coating to the drug through the encapsulation process for controlled release. The addition of Tripolyphosphate would change the characterization of Chitosan-Alginate microparticles because of the process of cross link. This study aims to determine the characterization of microparticles of Chitosan-Alginate based on particle size distribution, particle surface morphology and dissolution process in acid medium. The method used to make microparticles of Chitosan-Alginate using spray drying, microparticles can be made by mixing Chitosan-Alginate with a weight ratio of 1: 1, 1: 2, 2: 1 then mixed the crosslinking compound Tripolyphosphate (TPP) with a concentration of 0.1%, 0.3%, 0.5%, and added emulsifier Tween 80 3% v / v, stirred at a speed of 20,000 rpm for 10 minutes then inserted into the spray dryer to form microparticles. The powder of microparticles then analyzed by Scanning Electron Microscopy (SEM) and performed in vitro of stomach acid solution using acidic medium for the test of dissolution. Based on the research that has been done, 0.1% TPP concentration of Chitosan-Alginate ratio of 2: 1 can produce the most uniform size distribution with a ratio of 40.54%. The biggest dissolution of microparticles obtained from the samples with Chitosan-Alginate ratio of 2: 1 with a concentration of 0.1% TPP was 80.8%.

Keywords:

microparticle; chitosan-alginate; tripolyphosphate; spray dryer

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