DOI : https://doi.org/10.18517/ijaseit.2.4.208

Synthesis and Antibacterial Activity of Thiophenes

Wedad M. Al-Adiwish (1), W. A. Yaacob (2), D. Adan (3), I. Nazlina (4)
(1) School of Chemical Sciences and Food Technology, Universiti Kebangsaan Malaysia
(2) School of Chemical Sciences and Food Technology,Universiti Kebangsaan Malaysia
(3) School of Chemical Sciences and Food Technology, Universiti Kebangsaan Malaysia
(4) School of Biosciences and Biotechnology, Universiti Kebangsaan Malaysia
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How to cite (IJASEIT) :
Al-Adiwish, Wedad M., et al. “Synthesis and Antibacterial Activity of Thiophenes”. International Journal on Advanced Science, Engineering and Information Technology, vol. 2, no. 4, Aug. 2012, pp. 298-01, doi:10.18517/ijaseit.2.4.208.
Citation Format :
2-[Bis(methylthio)methylene]propanedinitrile 1a reacted in one-pot successively with piperidine, sodium sulfide, chloroacetonitrile, and potassium carbonate to afford 3-amino-5-(1-piperidinyl)-2,4-thiophenedicarbonitrile 2a. Similar reaction using the last three reagents with ethyl 2-cyano-3,3-bis(methylthio)acrylate 1b produced ethyl 4-amino-5-cyano-2-(methylthio)thiophene-3-carboxylate 2b. The synthesized compounds were characterized by using FT-IR, 1H-NMR, 13C-NMR, and mass spectral data. Antibacterial activities of the synthesized compounds are also reported.
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