DOI : https://doi.org/10.18517/ijaseit.4.3.383

Structural, Antioxidant and Antivarial Studies of C-3-nitrophenyl CALIX[4]resorcinarene

Bohari M Yamin (1), Hamza M Abosadiya (2), Siti Aisah Hasbullah (3), Jumina Jumina (4)
(1) School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia
(2) School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia
(3) School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University, Indonesia
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How to cite (IJASEIT) :
M Yamin, Bohari, et al. “Structural, Antioxidant and Antivarial Studies of C-3-Nitrophenyl CALIX[4]resorcinarene”. International Journal on Advanced Science, Engineering and Information Technology, vol. 4, no. 3, June 2014, pp. 125-8, doi:10.18517/ijaseit.4.3.383.
Citation Format :
The calix[4]arene derivative C-3-nitrophenylcalix[4]resorcinarene was synthesized by using one-pot reaction of resorcinol with 3-nitrobenzaldehyde in the presence of concentrated HCl. The compound  was characterized by IR, 1H and 13C NMR spectroscopy. X-ray crystallographic study showed that this compound crystallized in a triclinic system with space group of PÄ« and the unit cell dimensions, a = 10.6143(3) í… ,b = 13.6262(4) í…, c = 14.7971(5) í…, α = 102.813(3)°, β = 110.917(3)°, γ = 90.885(2)°. V= 1938.78(11) í…3 and Z =2. The biological Studies were also investigated. It has a stromg antioxidant property and high antiviral activity against HSV-1 . Cytotoxicity testing on Vero cells showed that it is non-toxic, with a CC50 of more than 0.4 mg/mL. Moderate antibacterial activity.

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