Chemical Component Analysis of Marine Sponge Extract of Potentially Medicinal Based on Solvent Differences

Ismail Marzuki (1), Bambang Heri Isnawan (2), Muhammad Arnol (3), Rahmiyah (4), Suciati (5), Arfandi Amin (6), Laode Muhamad Hafizh (7), Ruzkiah Asaf (8), Admi Athirah (9), Deni Aulia (10)
(1) Department of Chemical Engineering, Fajar University, Makassar, South Sulawesi, Indonesia
(2) Department of Agrotechnology, Universitas Muhammadiyah Yogyakarta, DI Yogyakarta, Indonesia
(3) Research Center for Fishery National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia
(4) Research Center for Fishery National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia
(5) Research Center for Fishery National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia
(6) Research Center for Fishery National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia
(7) Research Center for Conservation of Marine and Inland Water Resources, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia
(8) Research Center for Conservation of Marine and Inland Water Resources, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia
(9) Research Center for Conservation of Marine and Inland Water Resources, National Research and Innovation Agency (BRIN), Cibinong, West Java, Indonesia
(10) Department of Fisheries Biology, Collage of Fisheries Science, Pukyong National University, Busan, Republic of Korea
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How to cite (IJASEIT) :
Marzuki, Ismail, et al. “Chemical Component Analysis of Marine Sponge Extract of Potentially Medicinal Based on Solvent Differences”. International Journal on Advanced Science, Engineering and Information Technology, vol. 14, no. 3, June 2024, pp. 1064-73, doi:10.18517/ijaseit.14.3.19865.
Tracing and characterizing marine natural materials with special medicinal abilities is important to obtain new materials to enrich the diversity of drugs to treat particular diseases. The identification of the chemical components of sponges is interesting, considering the uniqueness and several other abilities possessed by sponges that are thought to have medicinal potential. Searching for chemical components in sponge extracts is suspected to contain secondary metabolic substances with medicinal potential. The study aimed to identify the chemical components of sponge extract with potential medicinal value based on differences in solvents. The first extract on the sponge Clathria (Thalysias) reinwardti  Sp.1 (CTR) by maceration method using semi-polar solvents (methanol). The second extraction uses a separating funnel with two types of non-polar solvents (diethyl-ether and n-hexane). The chemical components of the three extracts were analyzed using a gas chromatography-mass spectrophotometer instrument. The identified chemical components of sponge extract generally belong to the class of free fatty acids and cholesterol. Investigation of identified compounds with medicinal value chemical components, for example, Cholestan-3.alpha.-ol, Ergosta-5, Hexadecanoic acid, 1-(2,6-Dichlorophenyl)-2-indolinone and Pyridine-3-carboxamide. Searching for chemical components with medicinal potential from sponge extracts is novelty research based on differences in solvents, a new method. Complementing the data from this research, it is necessary to carry out further and specific searches related to chemical components with medicinal properties, which can be carried out by chromatographic fractionation and testing the activity of the extract against bacteria. pathogens and parasitic fungi.

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