DOI : https://doi.org/10.18517/ijaseit.4.3.383

Structural, Antioxidant and Antivarial Studies of C-3-nitrophenyl CALIX[4]resorcinarene

Bohari M Yamin (1), Hamza M Abosadiya (2), Siti Aisah Hasbullah (3), Jumina Jumina (4)
(1) School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia
(2) School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia
(3) School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University, Indonesia
Fulltext View | Download
How to cite (IJASEIT) :
[1]
B. M Yamin, H. M Abosadiya, S. Aisah Hasbullah, and J. Jumina, “Structural, Antioxidant and Antivarial Studies of C-3-nitrophenyl CALIX[4]resorcinarene”, Int. J. Adv. Sci. Eng. Inf. Technol., vol. 4, no. 3, pp. 125–128, Jun. 2014.
Citation Format :
The calix[4]arene derivative C-3-nitrophenylcalix[4]resorcinarene was synthesized by using one-pot reaction of resorcinol with 3-nitrobenzaldehyde in the presence of concentrated HCl. The compound  was characterized by IR, 1H and 13C NMR spectroscopy. X-ray crystallographic study showed that this compound crystallized in a triclinic system with space group of PÄ« and the unit cell dimensions, a = 10.6143(3) í… ,b = 13.6262(4) í…, c = 14.7971(5) í…, α = 102.813(3)°, β = 110.917(3)°, γ = 90.885(2)°. V= 1938.78(11) í…3 and Z =2. The biological Studies were also investigated. It has a stromg antioxidant property and high antiviral activity against HSV-1 . Cytotoxicity testing on Vero cells showed that it is non-toxic, with a CC50 of more than 0.4 mg/mL. Moderate antibacterial activity.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).