Antihyperglycemic Effect of Propolis Extract from Two Different Provinces in Indonesia

Prevalence of diabetus mellitus (DM) in Indonesia is expected to grow larger, estimated to reach 21,3 million in 2030. The treatments that commonly used for this disease are diet, antidiabetic drug, and insulin replacement, give more burden to the patient caused by its cost. Various studies has been done to find an alternative way by using herbal ingredient, and one of them is bee propolis. Indonesia has a local bee species, Trigona sp, which has great potential to produce propolis. Goal of this study is to determine of the effect of this propolis administration to diabetic model rat. Raw propolis from Java and Sulawesi extracted by using ethanol with the ratio of 1:10 and diluted by prohylen glycol. Five white rats were taken as control negatif group and thirty four more rats induced by alloxan divided into six groups: positive control, insulin, Java propolis 100 & 200 mg, and Sulawesi propolis 100 & 200 mg. Blood glucose level was measured before and after administration of alloxan, and at first & second weeks of the experiment. Result show that propolis from Java and Sulawesi in doses of 100 & 200 mg is effective in decreasing blood glucose for each 244, 282, 427, and 59 mg/dL at first week, and 355, 341, 476, and 84 mg/dL at second week of experiments. The effect in propolis group is larger than control group. Sulawesi Propolis 100 mg show larger effect in decreasing blood glucose than insulin and others propolis groups after two weeks of treatment.