International Journal on Advanced Science, Engineering and Information Technology, Vol. 2 (2012) No. 4, pages: 298-301, DOI:10.18517/ijaseit.2.4.208

Synthesis and Antibacterial Activity of Thiophenes

Abstract

2-[Bis(methylthio)methylene]propanedinitrile 1a reacted in one-pot successively with piperidine, sodium sulfide, chloroacetonitrile, and potassium carbonate to afford 3-amino-5-(1-piperidinyl)-2,4-thiophenedicarbonitrile 2a. Similar reaction using the last three reagents with ethyl 2-cyano-3,3-bis(methylthio)acrylate 1b produced ethyl 4-amino-5-cyano-2-(methylthio)thiophene-3-carboxylate 2b. The synthesized compounds were characterized by using FT-IR, 1H-NMR, 13C-NMR, and mass spectral data. Antibacterial activities of the synthesized compounds are also reported.

Keywords:

ketene dithioacetals; thiophenes; antibacterial activity

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